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Effects of a 5-HT1B Receptor Agonist on Locomotion and Reinstatement of Cocaine-Conditioned Place Preference after Abstinence from Repeated Injections in Mice


Abstract 5-HT[subscript 1B] receptors (5-HT[subscript 1B]Rs) modulate behavioral effects of cocaine. Here we examined the effects of the 5-HT[subscript 1B]R agonist 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine (CP94253) on spontaneous and cocaine-induced locomotion and on cocaine-primed reinstatement of conditioned place preference (CPP) in male mice given daily repeated injections of either saline or cocaine (15 mg/kg, IP) for 20 days. In the locomotor activity experiment, testing occurred both 1 and 20 days after the final injection. In the CPP experiment, mice underwent conditioning procedures while receiving the last of their daily injections, which were given either during or ≥2 h after CPP procedures. The CPP procedur... (more)
Created Date 2017-10-10
Contributor Der-Ghazarian, Taleen (ASU author) / Call, Tanessa (ASU author) / Scott, Samantha (ASU author) / Dai, Kael (ASU author) / Brunwasser, Samuel (ASU author) / Noudali, Sean (ASU author) / Pentkowski, Nathan (ASU author) / Neisewander, Janet (ASU author) / College of Liberal Arts and Sciences / School of Life Sciences
Series FRONTIERS IN SYSTEMS NEUROSCIENCE
Type Text
Extent 10 pages
Language English
Identifier DOI: 10.3389/fnsys.2017.00073 / ISSN: 1662-5137
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Citation Der-Ghazarian, T. S., Call, T., Scott, S. N., Dai, K., Brunwasser, S. J., Noudali, S. N., . . . Neisewander, J. L. (2017). Effects of a 5-HT1B Receptor Agonist on Locomotion and Reinstatement of Cocaine-Conditioned Place Preference after Abstinence from Repeated Injections in Mice. Frontiers in Systems Neuroscience, 11. doi:10.3389/fnsys.2017.00073
Note View the article as published at https://www.frontiersin.org/articles/10.3389/fnsys.2017.00073/full
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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