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Evaluation of Recombinant Attenuated Salmonella Vaccine Strains for Broad Protection against Extraintestinal Pathogenic Escherichia coli


Abstract Antibiotic-resistant bacterial infections are difficult to treat, producing a burden on healthcare and the economy. Extraintestinal pathogenic Escherichia coli (ExPEC) strains frequently carry antibiotic resistance genes, cause infections outside of the intestine, and are causative agents of hospital-acquired infections. Developing a prevention strategy against this pathogen is challenging due to its antibiotic resistance and antigenic diversity. E. coli common pilus (ECP) is frequently found in ExPEC strains and may serve as a common antigen to induce protection against several ExPEC serotypes. In addition, live recombinant attenuated Salmonella vaccine (RASV) strains have been used to prevent Salmonella infection and can also be modified ... (more)
Created Date 2017-10-09
Contributor Maddux, Jacob (ASU author) / Stromberg, Zachary R. (Author) / Curtiss, Roy (ASU author) / Mellata, Melha (ASU author) / Biodesign Institute / College of Liberal Arts and Sciences / School of Life Sciences
Series FRONTIERS IN IMMUNOLOGY
Type Text
Extent 12 pages
Language English
Identifier DOI: 10.3389/fimmu.2017.01280 / ISSN: 1664-3224
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Citation Maddux, J. T., Stromberg, Z. R., Iii, R. C., & Mellata, M. (2017). Evaluation of Recombinant Attenuated Salmonella Vaccine Strains for Broad Protection against Extraintestinal Pathogenic Escherichia coli. Frontiers in Immunology, 8. doi:10.3389/fimmu.2017.01280
Note View the article as published at https://www.frontiersin.org/articles/10.3389/fimmu.2017.01280/full
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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