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FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death


Abstract Mof4 family associated protein 1 (MRFAP1) is a 14 kDa nuclear protein, which involves in maintaining normal histone modification levels by negatively regulating recruitment of the NuA4 (nucleosome acetyltransferase of H4) histone acetyltransferase complex to chromatin. MRFAP1 has been identified as one of the most up-regulated proteins after NEDD8 (neural precursor cell expressed developmentally down- regulated 8) inhibition in multiple human cell lines. However, the biological function of MRFAP1 and the E3 ligase that targets MRFAP1 for destruction remain mysterious. Here we show, by using an immunoprecipitation-based proteomics screen, that MRFAP1 is an interactor of the F-box protein FBXW8. MRFAP1 is degraded by means of the ubiquitin li... (more)
Created Date 2017-10-12
Contributor Li, Duan-Zhuo (Author) / Liu, Shun-Fang (Author) / Zhu, Lan (ASU author) / Wang, Yu-Xing (Author) / Chen, Yi-Xiang (Author) / Liu, Jie (Author) / Hu, Gang (Author) / Yu, Xin (Author) / Li, Jian (Author) / Zhang, Jin (Author) / Wu, Zhi-Xiang (Author) / Lu, Han (Author) / Liu, Wei (ASU author) / Liu, Bin (Author) / College of Liberal Arts and Sciences / School of Molecular Sciences / Biodesign Institute / Applied Structural Discovery
Series ONCOTARGET
Type Text
Extent 9 pages
Language English
Identifier DOI: 10.18632/oncotarget.21843 / ISSN: 1949-2553
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Citation Li, D., Liu, S., Zhu, L., Wang, Y., Chen, Y., Liu, J., . . . Liu, B. (2017). FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death. Oncotarget, 8(57). doi:10.18632/oncotarget.21843
Note The final version of this article, as published in Oncotarget, can be viewed online at: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=21843&path[]=69284
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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