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HDL particles incorporate into lipid bilayers – a combined AFM and single molecule fluorescence microscopy study


Abstract The process, how lipids are removed from the circulation and transferred from high density lipoprotein (HDL) – a main carrier of cholesterol in the blood stream – to cells, is highly complex. HDL particles are captured from the blood stream by the scavenger receptor, class B, type I (SR-BI), the so-called HDL receptor. The details in subsequent lipid-transfer process, however, have not yet been completely understood. The transfer has been proposed to occur directly at the cell surface across an unstirred water layer, via a hydrophobic channel in the receptor, or after HDL endocytosis. The role of the target lipid membrane for the transfer process, however, has largely been overlooked. Here, we studied at the single molecule level how HDL pa... (more)
Created Date 2017-11-21
Contributor Plochberger, Birgit (Author) / Rohrl, Clemens (Author) / Preiner, Johannes (Author) / Rankl, Christian (Author) / Brameshuber, Mario (Author) / Madl, Josef (Author) / Bittman, Robert (Author) / Ros, Robert (ASU author) / Sezgin, Erdinc (Author) / Eggeling, Christian (Author) / Hinterdorfer, Peter (Author) / Stangl, Herbert (Author) / Schutz, Gerhard J. (Author) / College of Liberal Arts and Sciences / Department of Physics
Series SCIENTIFIC REPORTS
Type Text
Extent 10 pages
Language English
Identifier DOI: 10.1038/s41598-017-15949-7 / ISSN: 2045-2322
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Citation Plochberger, B., Röhrl, C., Preiner, J., Rankl, C., Brameshuber, M., Madl, J., . . . Schütz, G. J. (2017). HDL particles incorporate into lipid bilayers – a combined AFM and single molecule fluorescence microscopy study. Scientific Reports, 7(1). doi:10.1038/s41598-017-15949-7
Note The final version of this article, as published in Scientific Reports, can be viewed online at: https://www.nature.com/articles/s41598-017-15949-7
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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