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Rapid diagnosis of new and relapse tuberculosis by quantification of a circulating antigen in HIV-infected adults in the Greater Houston metropolitan area


Abstract Background
HIV-associated immune defects inhibit tuberculosis (TB) diagnosis, promote development of extrapulmonary TB and paucibacillary pulmonary TB cases with atypical radiographic features, and increase TB relapse rates. We therefore assessed the diagnostic performance of a novel assay that directly quantitates serum levels of the Mycobacterium tuberculosis (Mtb) virulence factor 10-kDa culture filtrate protein (CFP-10) to overcome limitations associated with detecting Mtb bacilli in sputum or tissue biopsies.
Methods
This study analyzed HIV-positive adults enrolled in a large, population-based TB screening and surveillance project, the Houston Tuberculosis Initiative, between October 1995 and September 2004, and assigned case designati... (more)
Created Date 2017-11-01
Contributor Fan, Jia (ASU author) / Zhang, Hedong (Author) / Nguyen, Duc T. (Author) / Lyon, Christopher (ASU author) / Mitchell, Charles D. (Author) / Zhao, Zhen (Author) / Graviss, Edward A. (Author) / Hu, Ye (ASU author)
Series BMC MEDICINE
Type Text
Extent 10 pages
Language English
Identifier DOI: 10.1186/s12916-017-0952-z / ISSN: 1741-7015
Copyright
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Citation Fan, J., Zhang, H., Nguyen, D. T., Lyon, C. J., Mitchell, C. D., Zhao, Z., . . . Hu, Y. (2017). Rapid diagnosis of new and relapse tuberculosis by quantification of a circulating antigen in HIV-infected adults in the Greater Houston metropolitan area. BMC Medicine, 15(1). doi:10.1186/s12916-017-0952-z
Note The electronic version of this article is the complete one and can be found online at: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0952-z
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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