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Serum Immune Profiling for Early Detection of Cervical Disease


Abstract Background: The most recent (2012) worldwide estimates from International Agency for Research on Cancer indicate that approximately 528,000 new cases and 270,000 deaths per year are attributed to cervical cancer worldwide. The disease is preventable with HPV vaccination and with early detection and treatment of pre-invasive cervical intraepithelial neoplasia, CIN. Antibodies (Abs) to HPV proteins are under investigation as potential biomarkers for early detection.
Methods: To detect circulating HPV-specific IgG Abs, we developed programmable protein arrays (NAPPA) that display the proteomes of two low-risk HPV types (HPV6 and 11) and ten oncogenic high-risk HPV types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52 and 58). Arrays were probed with se... (more)
Created Date 2017-08-23
Contributor Ewaisha, Radwa (ASU author) / Panicker, Gitika (Author) / Maranian, Paul (ASU author) / Unger, Elizabeth R. (Author) / Anderson, Karen (ASU author) / Biodesign Institute / Personalized Diagnostics
Series THERANOSTICS
Type Text
Extent 10 pages
Language English
Identifier DOI: 10.7150/thno.21098 / ISSN: 1309-1042
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Citation Ewaisha, R., Panicker, G., Maranian, P., Unger, E. R., & Anderson, K. S. (2017). Serum Immune Profiling for Early Detection of Cervical Disease. Theranostics, 7(16), 3814-3823. doi:10.7150/thno.21098
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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