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A Simple Platform for the Rapid Development of Antimicrobials


Abstract Recent infectious outbreaks highlight the need for platform technologies that can be quickly deployed to develop therapeutics needed to contain the outbreak. We present a simple concept for rapid development of new antimicrobials. The goal was to produce in as little as one week thousands of doses of an intervention for a new pathogen. We tested the feasibility of a system based on antimicrobial synbodies. The system involves creating an array of 100 peptides that have been selected for broad capability to bind and/or kill viruses and bacteria. The peptides are pre-screened for low cell toxicity prior to large scale synthesis. Any pathogen is then assayed on the chip to find peptides that bind or kill it. Peptides are combined in pairs as s... (more)
Created Date 2017-12-14
Contributor Johnston, Stephen (ASU author) / Domenyuk, Valeriy (ASU author) / Gupta, Nidhi (ASU author) / Tavares Batista, Milene (ASU author) / Lainson, John (ASU author) / Zhao, Zhan-Gong (ASU author) / Lusk, Joel (ASU author) / Loskutov, Andrey (ASU author) / Cichacz, Zbigniew (ASU author) / Stafford, Phillip (ASU author) / Legutki, Joseph Barten (ASU author) / Diehnelt, Chris (ASU author) / Biodesign Institute / Innovations in Medicine / Ira A. Fulton Schools of Engineering / School of Biomedical and Health Systems Engineering
Series SCIENTIFIC REPORTS
Type Text
Extent 11 pages
Language English
Identifier DOI: 10.1038/s41598-017-17941-7 / ISSN: 2045-2322
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Citation Johnston, S. A., Domenyuk, V., Gupta, N., Batista, M. T., Lainson, J. C., Zhao, Z., . . . Diehnelt, C. W. (2017). A Simple Platform for the Rapid Development of Antimicrobials. Scientific Reports, 7(1). doi:10.1038/s41598-017-17941-7
Note The final version of this article, as published in Scientific Reports, can be viewed online at: http://www.nature.com/articles/s41598-017-17941-7
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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