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Impact of Sex Differences and Tumor Location on Survival Outcomes in Glioblastoma Patients Receiving Standard of Care

Abstract Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and is linked to poor survival in affected patients due to its invasive and aggressive nature. The potential role of sexual dimorphism in GBM outcomes has long been overlooked. Notably, males and females differ in tumor behavior across many cancers1, which may be attributable to differences in genetic makeup and physiology, and in GBM there is a difference in incidence rate between males and females. The aim of the study was to investigate sex differences in GBM patients and compare median survival outcomes (OS) and progression-free survival outcomes (PFS) between sexes based on tumor location, laterality, age, tumor volume, and extent of resection. Patients who r... (more)
Created Date 2018-05
Contributor Lorence, Julia (Author) / Swanson, Kristin (Thesis Director) / Massey, Susan Christine (Committee Member) / Rubin, Joshua (Committee Member) / College of Nursing and Health Innovation / School of Life Sciences / School of Mathematical and Natural Sciences / Barrett, The Honors College
Subject Glioblastoma / Sex Differences / Tumor Locations
Series Academic Year 2017-2018
Type Text
Extent 65 pages
Language English
Reuse Permissions All Rights Reserved
Collaborating Institutions Barrett, the Honors College
Additional Formats MODS / OAI Dublin Core / RIS

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