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Examining Dose-Response Effects in Randomized Experiments with Partial Adherence


Abstract Understanding how adherence affects outcomes is crucial when developing and assigning interventions. However, interventions are often evaluated by conducting randomized experiments and estimating intent-to-treat effects, which ignore actual treatment received. Dose-response effects can supplement intent-to-treat effects when participants are offered the full dose but many only receive a partial dose due to nonadherence. Using these data, we can estimate the magnitude of the treatment effect at different levels of adherence, which serve as a proxy for different levels of treatment. In this dissertation, I conducted Monte Carlo simulations to evaluate when linear dose-response effects can be accurately and precisely estimated in randomize... (more)
Created Date 2018
Contributor Mazza, Gina Lynn (Author) / Grimm, Kevin J (Advisor) / West, Stephen G (Advisor) / MacKinnon, David P (Committee member) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Subject Quantitative psychology / Statistics / Health sciences / confounding / dose-response / instrumental variable / intent-to-treat / randomized experiments / treatment nonadherence
Type Doctoral Dissertation
Extent 73 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Psychology 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis