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Molecular Profiling Plasma Extracellular Vesicles From Breast Cancer Patients


Abstract Extracellular vesicles (EVs) represent a heterogeneous population of small vesicles, consisting of a phospholipidic bilayer surrounding a soluble interior cargo. These vesicles play an important role in cellular communication by virtue of their protein, RNA, and lipid content, which can be transferred among cells. Peripheral blood is a rich source of circulating EVs. An analysis of EVs in peripheral blood could provide access to unparalleled amounts of biomarkers of great diagnostic, prognostic as well as therapeutic value. In the current study, a plasma EV enrichment method based on pluronic co-polymer was first established and characterized. Plasma EVs from breast cancer patients were then enriched, profiled and compared to non-cancer con... (more)
Created Date 2018
Contributor Zhong, Zhenyu (Author) / Spetzler, David (Advisor) / Yan, Hao (Advisor) / Lake, Douglas (Committee member) / Mangone, Marco (Committee member) / Arizona State University (Publisher)
Subject Molecular biology / Biochemistry / Anoikis / Biomarker / Breast Cancer / Extracellular Vesicles / KIAA0100 / Plasma
Type Doctoral Dissertation
Extent 242 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Molecular and Cellular Biology 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis
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