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Expression, Characterization, and Structural Studies of Anti-amyloid Antibody Fragments


Abstract Alzheimer’s disease is a major problem affecting over 5.7 million Americans. Although much is known about the effects of this neurogenerative disease, the exact pathogenesis is still unknown. One very important characteristic of Alzheimer’s is the accumulation of beta amyloid protein which often results in plaques. To understand these beta amyloid proteins better, antibody fragments may be used to bind to these oligomers and potentially reduce the effects of Alzheimer’s disease.

This thesis focused on the expression and crystallization the fragment antigen binding antibody fragment A4. A fragment antigen binding fragment was chosen to be worked with as it is more stable than many other antibody fragments. A4 is important in Alzheimer’s di... (more)
Created Date 2018
Contributor Colasurd, Paige (Author) / Nannenga, Brent (Advisor) / Mills, Jeremy (Committee member) / Varman, Arul (Committee member) / Arizona State University (Publisher)
Subject Chemical engineering / Biochemistry / Bioengineering / Alzheimer's disease / Antibody Expression / Fab / Toxic Oligomers
Type Masters Thesis
Extent 28 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Masters Thesis Chemical Engineering 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis