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Physiological and Genetic Mechanisms Underlying Variation in Anoxia Tolerance in Drosophila Melanogaster


Abstract The ability to tolerate bouts of oxygen deprivation varies tremendously across the animal kingdom. Adult humans from different regions show large variation in tolerance to hypoxia; additionally, it is widely known that neonatal mammals are much more tolerant to anoxia than their adult counterparts, including in humans. Drosophila melanogaster are very anoxia-tolerant relative to mammals, with adults able to survive 12 h of anoxia, and represent a well-suited model for studying anoxia tolerance. Drosophila live in rotting, fermenting media and a result are more likely to experience environmental hypoxia; therefore, they could be expected to be more tolerant of anoxia than adults. However, adults have the capacity to survive anoxic exposure t... (more)
Created Date 2018
Contributor Campbell, Jacob B (Author) / Harrison, Jon F (Advisor) / Gadau, Juergen (Committee member) / Call, Gerald B (Committee member) / Sweazea, Karen L (Committee member) / Rosenberg, Michael S (Committee member) / Arizona State University (Publisher)
Subject Physiology / Biology / Genetics / anoxia / ATP / DGRP / D. melanogaster / Ionic homeostasis / metabolomics
Type Doctoral Dissertation
Extent 176 pages
Language English
Copyright
Note Doctoral Dissertation Evolutionary Biology 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis
  adult survival genes.xlsx
45.3 KB application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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Description Results of GWAS for Adults Exposed to 6 H of Anoxia
  larval survival genes.xlsx
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Description Results of GWAS for Larvae Exposed to 1 H of Anoxia