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Engineering of Electrically Conductive Cardiac Microtissues to Study the Influence of Gold Nanomaterials on Maturation and Electrophysiology of Cardiomyocytes


Abstract Myocardial infarction (MI) remains the leading cause of mortality and morbidity in the U.S., accounting for nearly 140,000 deaths per year. Heart transplantation and implantation of mechanical assist devices are the options of last resort for intractable heart failure, but these are limited by lack of organ donors and potential surgical complications. In this regard, there is an urgent need for developing new effective therapeutic strategies to induce regeneration and restore the loss contractility of infarcted myocardium. Over the past decades, regenerative medicine has emerged as a promising strategy to develop scaffold-free cell therapies and scaffold-based cardiac patches as potential approaches for MI treatment. Despite the progress, t... (more)
Created Date 2018
Contributor Navaei, Ali (Author) / Nikkhah, Mehdi (Advisor) / Brafman, David (Committee member) / Migrino, Raymond Q. (Committee member) / Stabenfeldt, Sarah (Committee member) / Vernon, Brent (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Bioengineering / Materials Science / biomaterials / cardiomyocytes / conductive hydrogels / electrophysiology / gold nanomaterials / tissue engineering
Type Doctoral Dissertation
Extent 206 pages
Language English
Copyright
Note Doctoral Dissertation Biomedical Engineering 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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