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A Plant Based Vaccine for Necrotic Enteritis in Chickens


Abstract Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens, leading to an estimated 2 billion dollar global economic loss in the poultry industry annually. Traditionally, NE has been effectively controlled by antibiotics added to the diet of poultry. Concerns about increasing antibiotic resistance of poultry and human based pathogens have led to the consideration of alternative approaches for controlling disease, such as vaccination. NE causing strains of C. perfringens produce two major toxins, α-toxin and NetB. Immune responses against either toxin can provide partial protection against NE. We have developed a fusion protein combining a non-toxic carboxy-terminal domain of the α-toxin (PlcC) and an attenu... (more)
Created Date 2018
Contributor Hunter, Joseph G (Author) / Mason, Hugh (Advisor) / Mor, Tsafrir (Committee member) / Blattman, Joseph (Committee member) / Arizona State University (Publisher)
Subject Microbiology / Agriculture / Molecular biology / alpha toxin / Chickens / Clostridium perfringens / Necrotic enteritis / NetB / Vaccine
Type Masters Thesis
Extent 40 pages
Language English
Copyright
Note Masters Thesis Molecular and Cellular Biology 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis