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Nanoparticle Drug Delivery to Brain Tumors: From Intravenous to Intrathecal


Abstract Achieving effective drug concentrations within the central nervous system (CNS) remains one of the greatest challenges for the treatment of brain tumors. The presence of the blood-brain barrier and blood-spinal cord barrier severely restricts the blood-to-CNS entry of nearly all systemically administered therapeutics, often leading to the development of peripheral toxicities before a treatment benefit is observed. To circumvent systemic barriers, intrathecal (IT) injection of therapeutics directly into the cerebrospinal fluid (CSF) surrounding the brain and spinal cord has been used as an alternative administration route; however, its widespread translation to the clinic has been hindered by poor drug pharmacokinetics (PK), including rapid ... (more)
Created Date 2018
Contributor Householder, Kyle Thomas (Author) / Sirianni, Rachael W (Advisor) / Stabenfeldt, Sarah (Committee member) / Vernon, Brent (Committee member) / Caplan, Michael (Committee member) / Wechsler-Reya, Robert (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Nanotechnology / Oncology / Cerebrospinal Fluid / Glioblastoma / Leptomeningeal Metastasis / Medulloblastoma / Nanoparticle
Type Doctoral Dissertation
Extent 115 pages
Language English
Copyright
Note Doctoral Dissertation Biomedical Engineering 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis