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Modeling, Design, Fabrication, and Characterization of a Highly Sensitive Fluorescence-based Detection Platform for Point-of-Care Applications


Abstract Over the past several decades, there has been a growing interest in the use of fluorescent probes in low-cost diagnostic devices for resource-limited environments. This dissertation details the design, development, and deployment of an inexpensive, multiplexed, and quantitative, fluorescence-based lateral flow immunoassay platform, in light of the specific constraints associated with resource-limited settings.

This effort grew out of the need to develop a highly sensitive, field-deployable platform to be used as a primary screening and early detection tool for serologic biomarkers for the high-risk human papillomavirus (hrHPV) infection. A hrHPV infection is a precursor for developing high-grade cervical intraepithelial neoplasia (CIN 2/3+... (more)
Created Date 2018
Contributor Obahiagbon, Uwadiae (Author) / Blain Christen, Jennifer M (Advisor) / Anderson, Karen S (Committee member) / Goryll, Michael (Committee member) / Smith, Barbara S (Committee member) / Arizona State University (Publisher)
Subject Electrical engineering / Biomedical engineering / Engineering / Colorimetry and absorbance / Human papillomavirus / Low and middle income countries / Low-cost diagnostics / sensitivity and specificity / Multiplexed fluorescence lateral flow assay / Point-of-care limit of detection
Type Doctoral Dissertation
Extent 280 pages
Language English
Copyright
Note Doctoral Dissertation Electrical Engineering 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis