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Epigenetic Dysregulation in the Basocortical Cholinergic Projection System During the Progression of Alzheimer's Disease


Abstract Alzheimer’s disease (AD) is characterized by the degeneration of cholinergic basal forebrain (CBF) neurons in the nucleus basalis of Meynert (nbM), which provides the majority of cholinergic input to the cortical mantle and together form the basocortical cholinergic system. Histone deacetylase (HDAC) dysregulation in the temporal lobe has been associated with neuronal degeneration during AD progression. However, whether HDAC alterations play a role in cortical and cortically-projecting cholinergic nbM neuronal degeneration during AD onset is unknown. In an effort to characterize alterations in the basocortical epigenome semi-quantitative western blotting and immunohistochemistry were utilized to evaluate HDAC and sirtuin (SIRT) levels in in... (more)
Created Date 2018
Contributor Mahady, Laura Jean (Author) / Mufson, Elliott J (Advisor) / Bimonte-Nelson, Heather (Advisor) / Coleman, Paul (Committee member) / Bowser, Robert (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Alzheimer's disease / epigenetics / histone deacetylases / mild cognitive impairment / neurofibrillary tangle / nucleus basalis of Meynert
Type Doctoral Dissertation
Extent 190 pages
Language English
Copyright
Note Doctoral Dissertation Neuroscience 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis