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Multiplexed Single-cell Spatial Proteomics and Transcriptomics

Abstract Single-cell proteomics and transcriptomics analysis are crucial to gain insights of

healthy physiology and disease pathogenesis. The comprehensive profiling of biomolecules in individual cells of a heterogeneous system can provide deep insights into many important biological questions, such as the distinct cellular compositions or regulation of inter- and intracellular signaling pathways of healthy and diseased tissues. With multidimensional molecular imaging of many different biomarkers in patient biopsies, diseases can be accurately diagnosed to guide the selection of the ideal treatment.

As an urgent need to advance single-cell analysis, imaging-based technologies have been developed to detect and quantify multiple DNA, RNA and protein... (more)
Created Date 2018
Contributor Mondal, Manas (Author) / Guo, Jia (Advisor) / Gould, Ian (Committee member) / Ros, Alexandra (Committee member) / Arizona State University (Publisher)
Subject Analytical chemistry / Biology / Biochemistry
Type Doctoral Dissertation
Extent 178 pages
Language English
Note Doctoral Dissertation Chemistry 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis