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Circulating Biomarkers for Cancer Immunoprofiling

Abstract Biomarkers find a wide variety of applications in oncology from risk assessment to diagnosis and predicting and monitoring recurrence and response to therapy. Developing clinically useful biomarkers for cancer is faced with several challenges, including cancer heterogeneity and factors related to assay development and biomarker performance. Circulating biomarkers offer a rapid, cost-effective, and minimally-invasive window to disease and are ideal for population-based screening. Circulating immune biomarkers are stable, measurable, and can betray the underlying antigen when present below detection levels or even no longer present. This dissertation aims to investigate potential circulating immune biomarkers with applications in cancer detec... (more)
Created Date 2018
Contributor Ewaisha, Radwa Mohamed Emadeldin Mahmoud (Author) / Anderson, Karen S (Advisor) / LaBaer, Joshua (Committee member) / Lake, Douglas F (Committee member) / Stout, Valerie (Committee member) / Arizona State University (Publisher)
Subject Immunology / Oncology / Health sciences / Biomarkers / Cancer Circulating Biomarkers / Cervical Cancer Detection / CRISPR/Cas9 Immunogenicity / Human Papillomavirus / Protein Arrays
Type Doctoral Dissertation
Extent 220 pages
Language English
Note Doctoral Dissertation Molecular and Cellular Biology 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis