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Mechanisms of MiRNA-based Gene Regulation in C. elegans and Human Cells

Abstract Multicellular organisms use precise gene regulation, executed throughout development, to build and sustain various cell and tissue types. Post-transcriptional gene regulation is essential for metazoan development and acts on mRNA to determine its localization, stability, and translation. MicroRNAs (miRNAs) and RNA binding proteins (RBPs) are the principal effectors of post-transcriptional gene regulation and act by targeting the 3'untranslated regions (3'UTRs) of mRNA. MiRNAs are small non-coding RNAs that have the potential to regulate hundreds to thousands of genes and are dysregulated in many prevalent human diseases such as diabetes, Alzheimer's disease, Duchenne muscular dystrophy, and cancer. However, the precise contribut... (more)
Created Date 2019
Contributor Kotagama, Kasuen Indrajith Bandara (Author) / Mangone, Marco (Advisor) / LaBaer, Joshua (Committee member) / Newbern, Jason (Committee member) / Rawls, Alan (Committee member) / Arizona State University (Publisher)
Subject Genetics / Molecular biology / Cellular biology / 3' untranslated regions / Alternative splicing / C. elegans / MicroRNA / Post transcriptional gene regulation / Transcriptome
Type Doctoral Dissertation
Extent 160 pages
Language English
Note Doctoral Dissertation Molecular and Cellular Biology 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis