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Modeling Emergent Behaviors of Multi-Cellular Systems in 3D Extracellular Matrix: Heterogeneous Extracellular Matrix Reconstruction, Cell Micromechanics and Novel Mechanotaxis

Abstract Collective cell migration in the 3D fibrous extracellular matrix (ECM) is crucial to many physiological and pathological processes such as tissue regeneration, immune response and cancer progression. A migrating cell also generates active pulling forces, which are transmitted to the ECM fibers via focal adhesion complexes. Such active forces consistently remodel the local ECM (e.g., by re-orienting the collagen fibers, forming fiber bundles and increasing the local stiffness of ECM), leading to a dynamically evolving force network in the system that in turn regulates the collective migration of cells.

In this work, this novel mechanotaxis mechanism is investigated, i.e., the role of the ECM mediated active cellular force propagation in coo... (more)
Created Date 2019
Contributor Nan, Hanqing (Author) / Jiao, Yang (Advisor) / Alford, Terry (Committee member) / Zhuang, Houlong (Committee member) / Arizona State University (Publisher)
Subject Materials Science
Type Doctoral Dissertation
Extent 102 pages
Language English
Note Doctoral Dissertation Materials Science and Engineering 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis