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Gut Microbiome Diversity and Community Structure Following Dietary Genistein Treatment in a Murine Model of Cystic Fibrosis


Abstract Introduction: Cystic fibrosis (CF) is the most common life-shortening autosomal recessive genetic disease affecting Caucasians. The disease is characterized by a dysfunctional cystic fibrosis transmembrane regulator (CFTR) protein and aberrant mucus accumulation that subsequently alters the physicochemical environment in numerous organ systems. These mucosal perturbations have been associated with inflammation and microbial dysbiosis, most notably in the lungs and gastrointestinal (GI) tract. Genistein, a soy isoflavone and dietary polyphenol, has been shown to modulate CFTR function in cell cultures and murine models, as well exert sex-dependent improvement of survival rates in a CF mouse model. However, it is unknown whether dietary genis... (more)
Created Date 2019
Contributor Argo, Katy Bryana (Author) / Whisner, Corrie M (Advisor) / Al-Nakkash, Layla (Committee member) / Sweazea, Karen L (Committee member) / Arizona State University (Publisher)
Subject Nutrition / cystic fibrosis / diet / genistein / microbiome
Type Masters Thesis
Extent 112 pages
Language English
Copyright
Note Masters Thesis Nutrition 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis