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Sensing and Regulation from Nucleic Acid Devices

Abstract The highly predictable structural and thermodynamic behavior of deoxynucleic acid (DNA) and ribonucleic acid (RNA) have made them versatile tools for creating artificial nanostructures over broad range. Moreover, DNA and RNA are able to interact with biological ligand as either synthetic aptamers or natural components, conferring direct biological functions to the nucleic acid devices. The applications of nucleic acids greatly relies on the bio-reactivity and specificity when applied to highly complexed biological systems.

This dissertation aims to 1) develop new strategy to identify high affinity nucleic acid aptamers against biological ligand; and 2) explore highly orthogonal RNA riboregulators in vivo for constructing multi-input gene c... (more)
Created Date 2019
Contributor Zhou, Yu (Author) / Yan, Hao (Advisor) / Green, Alexander (Advisor) / Woodbury, Neal (Committee member) / Ros, Alexandra (Committee member) / Arizona State University (Publisher)
Subject Biochemistry / aptamer / bivalent / repressor / riboregulator / thrombin
Type Doctoral Dissertation
Extent 160 pages
Language English
Note Doctoral Dissertation Biochemistry 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis