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Synthesis of Redox Active Neuroprotective Therapeutic Agents

Abstract Mitochondria are energy-producing organelles present in eukaryotic cells. Energy as adenosine triphosphate (ATP) is produced at the end of a series of electron transfers called the electron transport chain (ETC). Such a highly coordinated and regulated series of electron transfer reactions give rise to a small percentage of electron leakage which, by the subsequent reduction of molecular oxygen, produce superoxide anions (O2.-). These anions initiate the production of additional highly reactive oxygen-containing radicals commonly known as reactive oxygen species (ROS). Although cells are equipped with endogenous antioxidant systems to minimize ROS accumulation, these endogenous defense systems become inadequate when ROS generation is increa... (more)
Created Date 2019
Contributor Bandyopadhyay, Indrajit (Author) / Hecht, Sidney M (Advisor) / Gould, Ian R (Committee member) / Trovitch, Ryan (Committee member) / Arizona State University (Publisher)
Subject Chemistry
Type Doctoral Dissertation
Extent 145 pages
Language English
Note Doctoral Dissertation Chemistry 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis