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Computational Design and Study of Structural and Dynamic Nucleic Acid Systems

Abstract DNA and RNA are generally regarded as one of the central molecules in molecular biology. Recent advancements in the field of DNA/RNA nanotechnology witnessed the success of usage of DNA/RNA as programmable molecules to construct nano-objects with predefined shapes and dynamic molecular machines for various functions. From the perspective of structural design with nucleic acid, there are basically two types of assembly method, DNA tile based assembly and DNA origami based assembly, used to construct infinite-sized crystal structures and finite-sized molecular structures. The assembled structure can be used for arrangement of other molecules or nanoparticles with the resolution of nanometers to create new type of materials. The dynamic nucle... (more)
Created Date 2019
Contributor Hong, Fan (Author) / Yan, Hao (Advisor) / Liu, Yan (Advisor) / Green, Alexander A. (Committee member) / Borges, Chad (Committee member) / Arizona State University (Publisher)
Subject Chemistry / DNA nanotechnology / Molecular diagnostic / Molecular programming / RNA synthetic biology / Self-assembly
Type Doctoral Dissertation
Extent 310 pages
Language English
Note Doctoral Dissertation Chemistry 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis