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Proteins and their Glycosylations as Diagnostic Biomarkers of Valley Fever


Abstract Valley Fever (VF), is a potentially lethal fungal pneumonia caused by Coccidioides spp., which is estimated to cause ~15-30% of all community-acquired pneumonias in the highly endemic Greater Phoenix and Tucson areas of Arizona. However, an accurate antigen-based diagnostic is still lacking. In order to identify protein and glycan antigen biomarkers of infection, I used a combination of genomics, proteomics and glycomics analyses to provide evidence of genus-specific proteins and glycosylations. The next goal was to determine if Coccidioides-specific glycans were present in biological samples from VF patients. Urine collected from 77 humans and 63 dogs were enriched for glycans and evaluated by mass spectrometry for Coccidioides-specific gl... (more)
Created Date 2019
Contributor Mitchell, Natalie Michelle (Author) / Lake, Douglas F (Advisor) / Bean, Heather D (Committee member) / Grys, Thomas E (Committee member) / Magee, Dewey M (Committee member) / Arizona State University (Publisher)
Subject Microbiology / Biomarker / Coccidioides / Coccidioidomycosis / Glycan / Protein / Valley Fever
Type Doctoral Dissertation
Extent 201 pages
Language English
Copyright
Note Doctoral Dissertation Microbiology 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis