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Functional Studies of Thermosensitive Transient Receptor Potential (TRP) Ion Channel Regulation


Abstract All organisms need to be able to sense and respond to their environment. Much of this process takes place via proteins embedded in the cell membrane, the border between a living thing and the external world. Transient receptor potential (TRP) ion channels are a superfamily of membrane proteins that play diverse roles in physiology. Among the 27 TRP channels found in humans and other animals, TRP melastatin 8 (TRPM8) and TRP vanilloid 1 (TRPV1) are the primary sensors of cold and hot temperatures, respectively. They underlie the molecular basis of somatic temperature sensation, but beyond this are also known to be involved in body temperature and weight regulation, inflammation, migraine, nociception, and some types of cancer. Because of the... (more)
Created Date 2019
Contributor Hilton, Jacob (Author) / Van Horn, Wade D (Advisor) / Levitus, Marcia (Committee member) / Ghirlanda, Giovanna (Committee member) / Arizona State University (Publisher)
Subject Biophysics / Physiology / Neurosciences / Ion Channels / PIRT / Sensory Physiology / Thermosensing / Transient Receptor Potential / TRPM8
Type Doctoral Dissertation
Extent 202 pages
Language English
Copyright
Note Doctoral Dissertation Biochemistry 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis