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Development of Dose Verification Detectors Towards Improving Proton Therapy Outcomes

Abstract The challenge of radiation therapy is to maximize the dose to the tumor while simultaneously minimizing the dose elsewhere. Proton therapy is well suited to this challenge due to the way protons slow down in matter. As the proton slows down, the rate of energy loss per unit path length continuously increases leading to a sharp dose near the end of range. Unlike conventional radiation therapy, protons stop inside the patient, sparing tissue beyond the tumor. Proton therapy should be superior to existing modalities, however, because protons stop inside the patient, there is uncertainty in the range. “Range uncertainty” causes doctors to take a conservative approach in treatment planning, counteracting the advantages offered by proton therapy.... (more)
Created Date 2019
Contributor Holmes, Jason (Author) / Alarcon, Ricardo (Advisor) / Bues, Martin (Committee member) / Galyaev, Eugene (Committee member) / Chamberlin, Ralph (Committee member) / Arizona State University (Publisher)
Subject Nuclear physics and radiation / Medical imaging / Applied physics / detection / imaging / medical physics / proton therapy / radiation / radiotherapy
Type Doctoral Dissertation
Extent 165 pages
Language English
Note Doctoral Dissertation Physics 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis