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Thermo-responsive Copolymers with Enzyme-dependent Lower Critical Solution Temperatures for Endovascular Embolization


Abstract Minimally invasive endovascular embolization procedures decrease surgery time, speed up recovery, and provide the possibility for more comprehensive treatment of aneurysms, arteriovenous malformations (AVMs), and hypervascular tumors. Liquid embolic agents (LEAs) are preferred over mechanical embolic agents, such as coils, because they achieve homogeneous filling of aneurysms and more complex angioarchitectures. The gold standard of commercially available LEAs is dissolved in dimethyl sulfoxide (DMSO), which has been associated with vasospasm and angiotoxicity. The aim of this study was to investigate amino acid substitution in an enzyme-degradable side group of an N-isopropylacrylamide (NIPAAm) copolymer for the development of a LEA that w... (more)
Created Date 2019
Contributor Rosas Gomez, Karime Jocelyn (Author) / Vernon, Brent (Advisor) / Weaver, Jessica (Committee member) / Pal, Amrita (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Chemistry / Organic chemistry / bioresponsive / Embolic agent / Enzyme-degradable / NIPAAm / Polymer / stimuli-responsive
Type Masters Thesis
Extent 71 pages
Language English
Copyright
Note Masters Thesis Biomedical Engineering 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis