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Foundational Studies for Array-based Electrophoretic Exclusion of Proteins


Abstract Disease prevention and personalized treatment will be impacted by the continued integration of protein biomarkers into medical practice. While there are already numerous biomarkers used clinically, the detection of protein biomarkers among complex matrices remains a challenging problem. One very important strategy for improvements in clinical application of biomarkers is separation/preconcentration, impacting the reliability, efficiency and early detection. Electrophoretic exclusion can be used to separate, purify, and concentrate biomarkers. This counterflow gradient technique exploits hydrodynamic flow and electrophoretic forces to exclude, enrich, and separate analytes. The development of this technique has evolved onto an array-based mi... (more)
Created Date 2019
Contributor Zhu, Fanyi (Author) / Hayes, Mark (Advisor) / Ros, Alexandra (Committee member) / Buttry, Daniel (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Analytical chemistry / Electrophoretic exclusion / Microfluidics / Protein
Type Doctoral Dissertation
Extent 186 pages
Language English
Copyright
Note Doctoral Dissertation Chemistry 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis