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Fabrication and Characterization of Panobinostat Loaded PLA-PEG Nanoparticles


Abstract Medulloblastoma is the most common malignant pediatric brain cancer and is classified into four different subgroups based on genetic profiling: sonic hedgehog (SHH), WNT, Group 3 and 4. Changes in gene expression often alter the progression and development of cancers. One way to control gene expression is through the acetylation and deacetylation of histones. More specifically in medulloblastoma SHH and Group 3, there is an increased deacetylation, and histone deacetylase inhibitors (HDACi) can be used to target this change. Not only can HDACi target increases in deacetylation, they are also known to induce cell cycle arrest and apoptosis. The combination of these factors has made HDACi a promising cancer therapeutic. Panobinostat, a hydrop... (more)
Created Date 2019
Contributor Dharmaraj, Shruti (Author) / Sirianni, Rachael W (Advisor) / Stabenfeldt, Sarah E (Advisor) / Vernon, Brent L (Committee member) / Arizona State University (Publisher)
Subject Nanotechnology / Neurosciences / Oncology
Type Masters Thesis
Extent 33 pages
Language English
Copyright
Note Masters Thesis Biomedical Engineering 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis