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Biophysical Characterization of Cancer Cell Phenotypes


Abstract Cancer is a serious health concern. Current treatments are limited due to certain subpopulations of cancer cells being resistant to chemotherapy and radiation. These subpopulations have been qualitatively identified but much work remains to quantify the abnormalities they exhibit such as irregular nuclear shape. This dissertation seeks to determine physical science methods which can identify and quantify the biological characteristics of cancer and non-cancer cells. For the first project, the deoxyribonucleic acid (DNA) and chromatin of cancer and non-cancer esophageal cells were quantified using spectrophotometry and atomic force microscopy. Then the cellular nucleus shape, chromocenters, nucleoli, and nuclear speckles were characterized u... (more)
Created Date 2019
Contributor ARIYASINGHE, NETHMI KANCHANA (Author) / Ros, Robert (Advisor) / Arizona State University (Publisher)
Subject Biophysics / Cancer biology
Type Doctoral Dissertation
Extent 106 pages
Language English
Copyright
Note Doctoral Dissertation Physics 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis