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Microfluidic Models of Tumor-Stroma Interactions to Study the Interplay of Cancer Cells with their Surrounding Microenvironment


Abstract According to the World Health Organization, cancer is one of the leading causes of death around the world. Although early diagnostics using biomarkers and improved treatments with targeted therapy have reduced the rate of cancer related mortalities, there remain many unknowns regarding the contributions of the tumor microenvironment to cancer progression and therapeutic resistance. The tumor microenvironment plays a significant role by manipulating the progression of cancer cells through biochemical and biophysical signals from the surrounding stromal cells along with the extracellular matrix. As such, there is a critical need to understand how the tumor microenvironment influences the molecular mechanisms underlying cancer metastasis to fa... (more)
Created Date 2018
Contributor Truong, Danh (Author) / Nikkhah, Mehdi (Advisor) / LaBaer, Joshua (Committee member) / Smith, Barbara (Committee member) / Mouneimne, Ghassan (Committee member) / Vernon, Brent (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Bioengineering / Biology
Type Doctoral Dissertation
Extent 237 pages
Language English
Copyright
Note Doctoral Dissertation Biomedical Engineering 2018
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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