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Variations in Menopause Etiology Affect Cognitive Outcomes: How Age, Menopause Type, and Exogenous Ovarian Hormone Exposures Across the Lifespan Impact the Trajectory of Brain Aging


Abstract Reproductive hormones are recognized for their diverse functions beyond reproduction itself, including a vital role in brain organization, structure, and function throughout the lifespan. From puberty to reproductive senescence, the female is characterized by inherent responsiveness to hormonal cyclicity. For most women, a natural transition to menopause occurs in midlife, wherein the endogenous hormonal milieu undergoes significant changes and marks the end of the reproductive life stage. Although most women experience natural menopause, many women will undergo gynecological surgery during their lifetime, which can lead to an abrupt surgical menopause. It is of critical importance to better understand how endogenous and exogenous reproduct... (more)
Created Date 2019
Contributor Koebele, Stephanie Victoria (Author) / Bimonte-Nelson, Heather A (Advisor) / Conrad, Cheryl D (Committee member) / DeNardo, Dale F (Committee member) / Newbern, Jason M (Committee member) / Reiman, Eric M (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Aging / Behavioral sciences / aging / brain / hysterectomy / memory / menopause / vcd
Type Doctoral Dissertation
Extent 495 pages
Language English
Copyright
Note Doctoral Dissertation Psychology 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis