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Biophysical Methods to Quantify Cancer Cells and Microengineered Cancer Tissues Properties


Abstract Mechanical properties, in particular elasticity, of cancer cells and their microenvironment are important in governing cancer cell fate, for example function, mobility, adhesion, and invasion. Among all tools to measure the mechanical properties, the precision and ease of atomic force microscopy (AFM) to directly apply force—in the range of Pico to micronewtons—onto samples—with length scales from nanometers to tens of micrometers—has made it a powerful tool to investigate the mechanics of materials. AFM is widely used to measure deformability and stiffness of soft biological samples. Principally, these samples are indented by the AFM probe and the forces and indentation depths are recorded. The generated force-indentation curves are fitted... (more)
Created Date 2019
Contributor Rahmani Eliato, Kiarash (Author) / Ros, Robert (Advisor) / Nikkhah, Mehdi (Committee member) / Ozkan, Sefika (Committee member) / Lindsay, Stuart (Committee member) / Arizona State University (Publisher)
Subject Biophysics
Type Doctoral Dissertation
Extent 147 pages
Language English
Copyright
Note Doctoral Dissertation Physics 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis