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Facile Fabrication of Meso-to-Macroscale Single-Molecule Arrays for High-Throughput Digital Assays

Abstract One of the single-most insightful, and visionary talks of the 20th century, “There’s plenty of room at the bottom,” by Dr. Richard Feynman, represented a first foray into the micro- and nano-worlds of biology and chemistry with the intention of direct manipulation of their individual components. Even so, for decades there has existed a gulf between the bottom-up molecular worlds of biology and chemistry, and the top-down world of nanofabrication. Creating single molecule nanoarrays at the limit of diffraction could incentivize a paradigm shift for experimental assays. However, such arrays have been nearly impossible to fabricate since current nanofabrication tools lack the resolution required for precise single-molecule spatial manipulation... (more)
Created Date 2019
Contributor Shetty, Rishabh M (Author) / Hariadi, Rizal F (Advisor) / Gopinath, Ashwin (Committee member) / Varsani, Arvind (Committee member) / Nikkhah, Mehdi (Committee member) / Tillery, Stephen H (Committee member) / Hu, Ye (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Nanotechnology / DNA origami / High-throughput / Low-cost digital diagnostics / Nanosphere lithography / Single molecule arrays / Single-molecule biophysics
Type Doctoral Dissertation
Extent 149 pages
Language English
Note Doctoral Dissertation Biomedical Engineering 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis