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Diffuse Brain Injury Incites Sexual Differences and Hypothalamic-Pituitary-Adrenal Axis Disruptions


Abstract Of the 2.87 million traumatic brain injuries (TBI) sustained yearly in the United States, 75% are diffuse injuries. A single TBI can have acute and chronic influences on the neuroendocrine system leading to hypothalamic-pituitary-adrenal axis (HPA) dysregulation and increased affective disorders. Preliminary data indicate TBI causes neuroinflammation in the hippocampus, likely due to axonal damage, and in the paraventricular nucleus of the hypothalamus (PVN), where no axonal damage is apparent. Mechanisms regulating neuroinflammation in the PVN are unknown. Furthermore, chronic stress causes HPA dysregulation and glucocorticoid receptor (GR)-mediated neuroinflammation in the PVN. The goal of this project was to evaluate neuroinflammation ... (more)
Created Date 2019
Contributor Ridgway, Samantha (Author) / Thomas, Theresa C (Advisor) / Newbern, Jason (Advisor) / Bimonte-Nelson, Heather (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Endocrinology / diffuse traumatic brain injury / hypothalamic pituitary adrenal Axis / microglia / sexual differences
Type Masters Thesis
Extent 81 pages
Language English
Copyright
Note Masters Thesis Biology 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis