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Neo-morphic missense mutant p53 proteins and the co-drivers promoting cell invasion


Abstract Phenotypic and molecular profiling demonstrates a high degree of heterogeneity in the breast tumors. TP53 tumor suppressor is mutated in 30% of all breast tumors and the mutation frequency in basal-like subtype is as high as 80% and co-exists with several other somatic mutations in different genes. It was hypothesized that tumor heterogeneity is a result of a combination of neo-morphic functions of specific TP53 driver mutations and distinct co-mutations or the co-drivers for each type of TP53 mutation. The 10 most common p53 missense mutant proteins found in breast cancer patients were ectopically expressed in normal-like mammary epithelial cells and phenotypes associated with various hallmarks of cancer examined. Supporting the hypothesis... (more)
Created Date 2019
Contributor Pal, Anasuya (Author) / LaBaer, Joshua (Advisor) / Roberson, Robert (Committee member) / Van Horn, Wade (Committee member) / Maley, Carlo (Committee member) / Arizona State University (Publisher)
Subject Molecular biology / Biochemistry / Cellular biology / Co-drivers / CRISPR-Cas9 / Functional genomics / Mutation / Neo-morphic activity / TP53
Type Doctoral Dissertation
Extent 270 pages
Language English
Copyright
Note Doctoral Dissertation Biochemistry 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis