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Investigating Strategies to Enhance Microbial Production of and Tolerance Towards Aromatic Biochemicals


Abstract Aromatic compounds have traditionally been generated via petroleum feedstocks and have wide ranging applications in a variety of fields such as cosmetics, food, plastics, and pharmaceuticals. Substantial improvements have been made to sustainably produce many aromatic chemicals from renewable sources utilizing microbes as bio-factories. By assembling and optimizing native and non-native pathways to produce natural and non-natural bioproducts, the diversity of biochemical aromatics which can be produced is constantly being improved upon. One such compound, 2-Phenylethanol (2PE), is a key molecule used in the fragrance and food industries, as well as a potential biofuel. Here, a novel, non-natural pathway was engineered in Escherichia coli... (more)
Created Date 2019
Contributor Machas, Michael Stafford (Author) / Nielsen, David R (Advisor) / Haynes, Karmella (Committee member) / Wang, Xuan (Committee member) / Nannenga, Brent (Committee member) / Varman, Arul (Committee member) / Arizona State University (Publisher)
Subject Chemical engineering / 2-phenylethanol / Aromatics / E. coli / Metabolic Engineering / Transcriptomics
Type Doctoral Dissertation
Extent 152 pages
Language English
Copyright
Note Doctoral Dissertation Chemical Engineering 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis