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Expression and Purification of HPV Proteins for Early Detection of Head and Neck Cancer


Abstract Recent studies have shown that human papillomavirus (HPV) plays a role in development of cancers, one of which is head and neck cancer. There is strong and consistent molecular evidence demonstrating that human papillomavirus (HPV) is an etiological cause of these oropharyngeal cancers. Despite the introduction of HPV vaccines, there is still an increase in human papillomavirus associated OPC (HPVOPC) and it is expected that the incidence of head and neck cancer, specifically oropharyngeal cancer (OPC) will increase. The aim of this study is to utilize human papillomavirus (HPV) seropositivity for rapid detection of HPV early specific antigen-antibodies using a lateral flow assay.

Human papillomavirus (HPV) 16 proteins of interest, E7, E6 ... (more)
Created Date 2019
Contributor Ladipo, Evelyn (Author) / Anderson, Karen S (Advisor) / Hogue, Brenda G (Committee member) / Hou, Ching-Wen (Committee member) / Arizona State University (Publisher)
Subject Virology / Molecular biology / Cellular biology / early proteins / head and neck cancer / human papillomavirus / rapid diagnosis
Type Masters Thesis
Extent 37 pages
Language English
Copyright
Note Masters Thesis Molecular and Cellular Biology 2019
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis