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Using Molecular, Cellular and Bioengineering Approaches Towards Understanding Muscle Stem Cell Biology


Abstract Satellite cells are adult muscle stem cells that activate, proliferate, and differentiate into myofibers upon muscle damage. Satellite cells can be cultured and manipulated in vitro, and thus represent an accessible model for studying skeletal muscle biology, and a potential source of autologous stem cells for regenerative medicine. This work summarizes efforts to further understanding of satellite cell biology, using novel model organisms, bioengineering, and molecular and cellular approaches. Lizards are evolutionarily the closest vertebrates to humans that regenerate entire appendages. An analysis of lizard myoprogenitor cell transcriptome determined they were most transcriptionally similar to mammalian satellite cells. Further examinati... (more)
Created Date 2020
Contributor Palade, Joanna (Author) / Wilson-Rawls, Norma (Advisor) / Rawls, Jeffrey (Committee member) / Kusumi, Kenro (Committee member) / Newbern, Jason (Committee member) / Stabenfeldt, Sarah (Committee member) / Arizona State University (Publisher)
Subject Biology / Cellular biology / Molecular biology / anole lizard / hydrogel / regeneration / satellite cells / skeletal muscle / stem cells
Type Doctoral Dissertation
Extent 133 pages
Language English
Copyright
Note Doctoral Dissertation Molecular and Cellular Biology 2020
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis