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Growing Human Organs in Animals: Interspecies Blastocyst Complementation as a Potential Solution for Organ Transplant Limitations

Abstract Prior to the first successful allogeneic organ transplantation in 1954, virtually every attempt at transplanting organs in humans had resulted in death, and understanding the role of the immune mechanisms that induced graft rejection served as one of the biggest obstacles impeding its success. While the eventual achievement of organ transplantation is touted as one of the most important success stories in modern medicine, there still remains a physiological need for immunosuppression in order to make organ transplantation work. One such solution in the field of experimental regenerative medicine is interspecies blastocyst complementation, a means of growing patient-specific human organs within animals. To address the progression of immune-r... (more)
Created Date 2020
Contributor Darby, Alexis Renee (Author) / Maienschein, Jane (Advisor) / Robert, Jason (Advisor) / Ellison, Karin (Committee member) / Arizona State University (Publisher)
Subject Biology / Science history / Immunology / immunosuppression / interspecies blastocyst complementation / interspecies chimeras / organ shortage / organ transplantation
Type Masters Thesis
Extent 77 pages
Language English
Note Masters Thesis Biology 2020
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis