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Emergence Of Biological Phenotypes With Subcellular Based Modeling: From Cells To Tissues


Abstract This dissertation features a compilation of studies concerning the biophysics of multicellular systems. I explore eukaryotic systems across length scales of the cell cytoskeleton to macroscopic scales of tissues. I begin with a general overview of the natural phenomena of life and a philosophy of investigating developmental systems in biology. The topics covered throughout this dissertation require a background in eukaryotic cell physiology, viscoelasticity, and processes of embryonic tissue morphogenesis. Following a brief background on these topics, I present an overview of the Subcellular Element Model (ScEM). This is a modeling framework which allows one to compute the dynamics of large numbers of three-dimensional deformable cells in m... (more)
Created Date 2011
Contributor Sandersius, Sebastian Ambrose (Author) / Newman, Timothy J (Advisor) / Rez, Peter (Committee member) / Ros, Robert (Committee member) / Sankey, Otto F. (Committee member) / Tsen, Kong-Thon (Committee member) / Arizona State University (Publisher)
Subject Biophysics / Biomechanics / Biology / cell migration / cell rheology / chick development / multicellular system / tissue mechanics / viscoelasticity
Type Doctoral Dissertation
Extent 138 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Physics 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis