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Enhancement of Polymer-mediated Transgene Expression using Chemotherapeutic Modulators of Intracellular Trafficking and Cell-Cycle Progression


Abstract Gene therapy is a promising technology for the treatment of various nonheritable and genetically acquired diseases. It involves delivery of a therapeutic gene into target cells to induce cellular responses against diseases. Successful gene therapy requires an efficient gene delivery vector to deliver genetic materials into target cells. There are two major classes of gene delivery vectors: viral and non-viral vectors. Recently, non-viral vectors such as cationic polymers have attracted more attention than viral vectors because they are versatile and non-immunogenic. However, cationic polymers suffer from poor gene delivery efficiency due to biological barriers. The objective of this research is to develop strategies to overcome the barriers... (more)
Created Date 2011
Contributor Barua, Sutapa (Author) / Rege, Kaushal (Advisor) / Dai, Lenore (Committee member) / Meldrum, Deirdre R. (Committee member) / Sierks, Michael (Committee member) / Voelkel-Johnson, Christina (Committee member) / Arizona State University (Publisher)
Subject Chemical Engineering
Type Doctoral Dissertation
Extent 201 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Chemical Engineering 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis