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Molecular Chaperones of the Endoplasmic Reticulum Promote Hepatitis C Virus E2 Protein Production in Plants


Abstract Infections caused by the Hepatitis C Virus (HCV) are very common worldwide, affecting up to 3% of the population. Chronic infection of HCV may develop into liver cirrhosis and liver cancer which is among the top five of the most common cancers. Therefore, vaccines against HCV are under intense study in order to prevent HCV from harming people's health. The envelope protein 2 (E2) of HCV is thought to be a promising vaccine candidate because it can directly bind to a human cell receptor and plays a role in viral entry. However, the E2 protein production in cells is inefficient due to its complicated matured structure. Folding of E2 in the endoplasmic reticulum (ER) is often error-prone, resulting in production of aggregates and misfolded... (more)
Created Date 2011
Contributor Hong, Fan (Author) / Mason, Hugh (Advisor) / Gaxiola, Roberto (Committee member) / Chang, Yung (Committee member) / Chen, Qiang (Committee member) / Arizona State University (Publisher)
Subject Biology / ER chaperone / HCV envelope protein E2
Type Masters Thesis
Extent 83 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note M.S. Biological Design 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis