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Mapping the RNA-Protein Interface in Telomerase RNP

Abstract In the 1970s James Watson recognized the inability of conventional DNA replication machinery to replicate the extreme termini of chromosomes known as telomeres. This inability is due to the requirement of a building block primer and was termed the end replication problem. Telomerase is nature's answer to the end replication problem. Telomerase is a ribonucleoprotein which extends telomeres through reverse transcriptase activity by reiteratively copying a short intrinsic RNA sequence to generate 3' telomeric extensions. Telomeres protect chromosomes from erosion of coding genes during replication, as well as differentiate native chromosome ends from double stranded breaks. However, controlled erosion of telomeres functions as a ... (more)
Created Date 2011
Contributor Bley, Christopher James (Author) / Chen, Julian (Advisor) / Allen, James (Committee member) / Ghirlanda, Giovanna (Committee member) / Arizona State University (Publisher)
Subject Biochemistry / Photo cross-linking / ribonucleoprotein / Telomerase
Type Doctoral Dissertation
Extent 176 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Chemistry 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis