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Identification, Characterization and Evolution of Invertebrate Telomerase RNA


Abstract Telomerase is a specialized enzyme that adds telomeric DNA repeats to the chromosome ends to counterbalance the progressive telomere shortening over cell divisions. It has two essential core components, a catalytic telomerase reverse transcriptase protein (TERT), and a telomerase RNA (TR). TERT synthesizes telomeric DNA by reverse transcribing a short template sequence in TR. Unlike TERT, TR is extremely divergent in size, sequence and structure and has only been identified in three evolutionarily distant groups. The lack of knowledge on TR from important model organisms has been a roadblock for vigorous studies on telomerase regulation. To address this issue, a novel in vitro system combining deep-sequencing and bioinformatics search was d... (more)
Created Date 2011
Contributor Li, Yang (Author) / Chen, Julian Jl (Advisor) / Yan, Hao (Committee member) / Ghirlanda, Giovanna (Committee member) / Arizona State University (Publisher)
Subject Molecular Biology / Biochemistry / RNA-protein interaction / RNA structure / function and evolution / telomerase / telomerase reverse transcriptase / telomerase RNA
Type Doctoral Dissertation
Extent 219 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Biochemistry 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis