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Optimizing Micro-vortex Chamber for Living Single Cell Rotation


Abstract Single cell phenotypic heterogeneity studies reveal more information about the pathogenesis process than conventional bulk methods. Furthermore, investigation of the individual cellular response mechanism during rapid environmental changes can only be achieved at single cell level. By enabling the study of cellular morphology, a single cell three-dimensional (3D) imaging system can be used to diagnose fatal diseases, such as cancer, at an early stage. One proven method, CellCT, accomplishes 3D imaging by rotating a single cell around a fixed axis. However, some existing cell rotating mechanisms require either intricate microfabrication, and some fail to provide a suitable environment for living cells. This thesis develops a microvorterx cha... (more)
Created Date 2011
Contributor Zhang, Wenjie (Author) / Frakes, David (Advisor) / Meldrum, Deirdre (Advisor) / Chao, Shih-Hui (Committee member) / Wang, Xiao (Committee member) / Arizona State University (Publisher)
Subject Biomedical Engineering / Engineering / cell ct / cfd / micro-piv / microvortex
Type Masters Thesis
Extent 71 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note M.S. Bioengineering 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


  Full Text
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Description Dissertation/Thesis
  trapezoidrotationWenjieNov182010.wmv
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Description Video of the irregular cell rotation