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The Synthetic Biology of a Man-Made Protein

Abstract Synthetic biology is constantly evolving as new ideas are incorporated into this increasingly flexible field. It incorporates the engineering of life with standard genetic parts and methods; new organisms with new genomes; expansion of life to include new components, capabilities, and chemistries; and even completely synthetic organisms that mimic life while being composed of non-living matter. We have introduced a new paradigm of synthetic biology that melds the methods of in vitro evolution with the goals and philosophy of synthetic biology. The Family B proteins represent the first de novo evolved natively folded proteins to be developed with increasingly powerful tools of molecular evolution. These proteins are folded and functional, co... (more)
Created Date 2011
Contributor Stomel, Joshua M. (Author) / Chaput, John C (Advisor) / Korch, Shaleen (Committee member) / Roberson, Robert (Committee member) / Ghirlanda, Gionvanna (Committee member) / Arizona State University (Publisher)
Subject Molecular Biology / Microbiology / DX / E. coli / Fillament / Stringent Response / Synthetic Biology
Type Doctoral Dissertation
Extent 277 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Biology 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis