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A Liquid-to-Solid Gelling Polymer System for Cerebral Aneurysm Embolization: Formulation, Characterization, and Testing

Abstract Treatment of cerebral aneurysms using non-invasive methods has existed for decades. Since the advent of modern endovascular techniques, advancements to embolic materials have largely focused on improving platinum coil technology. However, the recent development of Onyx®, a liquid-delivery precipitating polymer system, has opened the door for a new class of embolic materials--liquid-fill systems. These liquid-fill materials have the potential to provide better treatment outcomes than platinum coils. Initial clinical use of Onyx has proven promising, but not without substantial drawbacks, such as co-delivery of angiotoxic compounds and an extremely technical delivery procedure. This work focuses on formulation, characterization and testing of... (more)
Created Date 2011
Contributor Riley, Celeste (Author) / Vernon, Brent L (Advisor) / Preul, Mark C (Committee member) / Frakes, David (Committee member) / Pauken, Christine (Committee member) / Massia, Stephen (Committee member) / Arizona State University (Publisher)
Subject Biomedical Engineering / cerebral aneurysm / cross-linking polymer system / embolization / endovascular / liquid embolic material
Type Doctoral Dissertation
Extent 179 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Bioengineering 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis